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EXPAREL starts controlling pain during surgery, so that your recovery can begin

  • Only 1 dose, given by your doctor, so you have 1 less thing to manage
  • Provides pain control for the first few days after surgery, when you need it most, by numbing the area on your body where your surgery was performed
  • Works directly at the surgical site—unlike opioids, which affect your whole body
  • Clinical trials showed patients who got EXPAREL had less need for opioids*

*The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.



EXPAREL is indicated for single-dose infiltration in adults to produce postsurgical local analgesia and as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia. Safety and efficacy have not been established in other nerve blocks.


Important Safety Information

EXPAREL should not be used in obstetrical paracervical block anesthesia.

In studies where EXPAREL was injected into the wound, the most common side effects were


What should you know about opioid pain medications?

Opioids are often used to provide pain control after surgery. While these medications can reduce pain, they can also have side effects, such as nausea, vomiting, and constipation. As many as 1 in 4 people experience nausea.1 Opioids can make you feel drowsy or confused. For some people, their body can get used to opioids over time; this is called tolerance. They may need higher doses of opioids to get the same kind of relief. This tolerance can increase their risk of long-term use or dependence.1,2


What should you know about non-opioid pain medications?

Non-opioid medications also reduce pain, but without the risk of opioid side effects or opioid dependence. There are 2 types of non-opioids that are commonly used by doctors: systemic medications and local anesthetics.

Systemic medications work on the whole body, not just where you feel pain. These include acetaminophen (Tylenol®) and non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, celecoxib (eg, Celebrex®), ibuprofen (eg, Advil®, Motrin®), and naproxen (eg, Aleve®, Naprosyn®).

Local anesthetics, such as EXPAREL, work directly at the surgical site to numb the nerves that cause pain. What makes EXPAREL unique is that it slowly releases a local anesthetic, bupivacaine, over time to provide prolonged pain relief.


What should you know about EXPAREL?

EXPAREL is an alternative to opioids that offers long-lasting pain relief. It can be injected into your shoulder before or at the end of surgery by your orthopedic surgeon. EXPAREL can also be injected as a nerve block by an anesthesiologist to numb the nerves in your shoulder. As a result, the need for opioid medications during your recovery may be reduced or eliminated.*

*The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials. All products, names, and brands are the property of their respective owners.